Delta-9 THC is the most well-researched and well-known form of THC, the main psychoactive compound in cannabis that causes the “high”.
THC works by interacting with the endocannabinoid system (ECS) in the body, which is responsible for maintaining balance and homeostasis.
Delta-9 THC binds to the cannabinoid receptors in the brain and body, leading to a range of effects, such as euphoria, relaxation, pain relief, increased appetite, and altered perception.
ECS has three primary components: endocannabinoids, cannabinoid receptors, and enzymes. Endocannabinoids are molecules that are naturally produced by the body and act as messengers between cells.
Cannabinoid receptors are proteins that are located on the surface of cells and receive signals from endocannabinoids or phytocannabinoids, such as THC.
Enzymes break down endocannabinoids or cannabinoids after they have completed their function.
There are two main types of cannabinoid receptors: CB1 and CB2.
CB1 receptors are mostly found in the brain and central nervous system and CB2 receptors, which are mostly found in the immune system and peripheral tissues.
Delta-9 THC has a high affinity for CB1 receptors, which means it can bind strongly to them and activate them. This activation leads to the release of neurotransmitters, such as dopamine, serotonin, and glutamate, which affect mood, cognition, memory, and perception.
Delta-9 THC can also modulate the activity of other neurotransmitter systems, such as GABA, opioid, and serotonin, which can influence pain sensation, anxiety, and sleep.
Delta-9 THC can also bind to CB2 receptors, but with a lower affinity for them.
CB2 receptors are involved in regulating inflammation, immune response, and cell growth.
CBD however, has a higher affinity to CB2 receptors which means CBD + THC Gummies provide more profound, deeper effects than either by itself.
For example, CBD can counteract some of the negative effects of THC, such as anxiety and paranoia.