CBD vs Delta-8: Comprehensive Guide

The natural wellness landscape has changed dramatically since cannabinoids like CBD first gained mainstream attention.

Today, one in three Americans has tried CBD products, with active users growing from 14% in 2019 to 26% in 2022.

Delta-8 THC has also gained significant popularity, though with some concerning statistics—poison centers reported nearly 2,000 Delta-8 related poisoning cases in 2024 alone, with almost 10,000 cases documented between 2021 and 2024.

Both compounds offer distinct paths to wellness. CBD brings therapeutic benefits without the mind-altering effects, while Delta-8 can be considered a gentler alternative to Delta-9 THC.

Let’s break down everything you need to know about choosing between CBD and Delta-8 THC.

Key Differences at a Glance

• Psychoactivity:

• CBD: Non-intoxicating; may subtly influence mood without causing a “high.”

• Delta-8 THC: Mildly psychoactive; can lead to euphoria or relaxation but is typically less intense than Delta-9 THC.

• Extraction and Production:

• CBD: Directly extracted from hemp plants using methods like CO₂ or ethanol-based extraction. We use solventless extraction - Cellular Deconstruction™ Technology, which uses physics instead of chemicals to deliver cleaner, more bioavailable, and highly effective extracts.

• Delta-8 THC: Often synthesized from CBD through chemical processes to achieve sufficient concentrations.

• Potential Benefits:

• CBD: Commonly used for stress management, inflammation support, and general well-being.

• Delta-8 THC: May offer milder euphoria and relaxation; sometimes chosen for appetite stimulation or easing tension.

• Legality and Regulation:

• CBD: Federally legal if derived from hemp with less than 0.3% THC, though state laws can vary.

• Delta-8 THC: Considered federally legal under certain interpretations of the 2018 Farm Bill, but some states ban or restrict it due to ongoing regulatory debates.

What Are Cannabinoids?

Cannabinoids are naturally occurring compounds found in cannabis plants, including hemp and marijuana. Scientists have identified more than 133 of these compounds so far, each with unique properties and effects. 

Two of the most talked-about cannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC), both of which have seen a surge in usage nationwide.

How Do They Interact With the Body?

Cannabinoids engage with a network of receptors known as the endocannabinoid system (ECS). 

This system helps regulate essential functions such as mood, stress responses, pain perception, and even immune function. 

When cannabinoids like CBD or Delta-8 THC bind ( or indirectly interact) with these receptors—primarily CB1 and CB2—they can influence how we feel both mentally and physically.

Why Are They Important?

Because of their widespread influence on various bodily processes, cannabinoids have become a focal point for researchers exploring new ways to support overall well-being. 

People often look to cannabinoids for everyday stress, better sleep quality, and to maintain a sense of balance.

While each cannabinoid has unique properties, the growing body of research suggests they may complement one another when used responsibly.

What Is CBD?

CBD (cannabidiol) is among the most prominent cannabinoids extracted from hemp—a variety of cannabis that contains 0.3% or less THC by dry weight.

Unlike Delta-9 THC (the well-known psychoactive compound in marijuana), CBD is non-intoxicating and generally associated with stress relief, mood support, and potential anti-inflammatory benefits.

Studies over the past few years have shown a substantial rise in CBD use for wellness purposes, with many individuals reporting improvements in sleep quality and overall relaxation.

What Is Delta-8 THC?

Delta-8 THC is another cannabinoid found in trace amounts in hemp plants. Commercially, it’s often produced through a chemical process that converts CBD into Delta-8, primarily because its natural concentrations in hemp are so low.

Though Delta-8 THC is less potent than Delta-9 THC, it still has a mild to moderate psychoactive effect.

Users often describe it as a more subdued experience—potentially helpful for relaxation but still capable of altering perception.

Choosing between CBD and Delta-8 THC generally comes down to your personal preferences and wellness goals.

If you’re seeking non-intoxicating, daily support for stress or discomfort, CBD might be the better fit.

If a mild psychoactive effect aligns with your needs—perhaps for winding down at the end of the day—Delta-8 could offer a gentler alternative to conventional THC products.

How Does CBD Interact with the Endocannabinoid System?

While often linked to the CB1 and CB2 receptors within the endocannabinoid system (ECS), CBD does not directly bind to these receptors the way Delta-8 THC or Delta-9 THC does. Instead, it acts as an indirect modulator. 

For instance, CBD can influence levels of the endocannabinoid anandamide (often referred to as the “bliss molecule”) by inhibiting the enzyme responsible for breaking it down, helping maintain a sense of balance or homeostasis. 

Current research also suggests that instead of functioning as an agonist like Delta-9 THC or Delta-8 THC, CBD may work as a partial agonist or a subtle modulator on CB2 receptors. 

This interaction may contribute to its potential anti-inflammatory effects, particularly in synergy with other targets like TRPV1 (involved in pain regulation) and PPARγ (linked to inflammation and metabolic processes).

Why Is CBD Considered “Non-Intoxicating”?

One of the most common misconceptions about CBD is that it’s entirely “non-psychoactive.” 

A more accurate description is that it’s non-intoxicating—and only mildly psychoactive. CBD can influence mood, anxiety, and stress responses through its action on serotonin receptors (5HT1A), as well as by modulating other receptor systems in the body. 

Despite these effects, CBD doesn’t produce the “high” associated with THC.

How Is Delta-8 THC Different?

Delta-8 THC binds directly to CB1 receptors in the central nervous system, though with slightly less affinity than Delta-9 THC.

This direct binding results in a mild to moderate psychoactive effect, which many people find less intense than the Delta-9 THC products. 

While Delta-8 may provide a sense of relaxation or euphoria, it can also carry some of the same side effects as other forms of THC, such as dry mouth, red eyes, or feelings of sedation, especially at higher doses.

Effects and Benefits

CBD Benefits & Effects

CBD is widely recognized for its potential therapeutic properties, with research continually uncovering new ways this cannabinoid interacts with the body. 

People turn to CBD for its calming effects, as it interacts with serotonin receptors (5HT1A) to help regulate mood and anxiety.

Additionally, its anti-inflammatory properties are believed to be mediated through interactions with CB2 receptors, TRPV1 (vanilloid receptors), and PPARγ.

These mechanisms may help alleviate discomfort associated with chronic pain and inflammation-related conditions.

Studies also highlight CBD’s neuroprotective potential, with ongoing research into its effects on conditions like epilepsy, multiple sclerosis, and even neurodegenerative diseases.

Furthermore, many users report improved sleep quality, better focus, and overall stress reduction when incorporating CBD into their routines.

Importantly, CBD is non-intoxicating, making it an appealing option for those seeking wellness benefits without a psychoactive experience.

Delta-8 Benefits & Effects

Delta-8 THC is often said to be milder than Delta-9 THC, but it doesn’t have the same potency. If you’re looking for a strong restorative or recreational effect, Delta-8 may not be enough. It can give you a relaxing and slightly euphoric effect, but it doesn’t have the same intensity and range of effects as Delta-9 THC.

Delta-9 is the strongest and most potent cannabinoid in the cannabis plant. It provides quick relief, deep relaxation and euphoria. It is the most popular cannabinoid for medical use and for recreational use. This is because it is naturally occurring and directly interacts with the cannabinoid receptors in the body.

Delta-8, just like Delta-9 THC, binds directly to CB1 and CB2 receptors in the endocannabinoid system, contributing to its ability to influence mood, appetite, and perception.

However, Delta-8 THC’s psychoactive nature may not be suitable for everyone, especially for those who want to avoid any mind-altering effects. 

Delta-8 vs CBD for Sleep

Both CBD and Delta-8 THC may assist in improving sleep quality, but they do so in different ways.

• CBD: Often used to promote restful sleep indirectly by addressing underlying issues like anxiety, discomfort, or stress. Research suggests that CBD may help regulate sleep cycles by interacting with serotonin receptors and enhancing relaxation.

• Delta-8 THC: More directly sedative, Delta-8 THC’s psychoactive properties can help some users feel drowsy or relaxed enough to fall asleep. However, its effectiveness depends heavily on your tolerance and previous experience with THC products.

For sleep, CBD is typically preferred by those who want a non-intoxicating option, while Delta-8 THC may be better if you’re comfortable with mild psychoactive effects.

Delta-8 vs CBD for Anxiety

When it comes to managing anxiety, both cannabinoids have appeal, though their modes of action and effects differ significantly:

• CBD: Known for its anxiolytic properties, CBD interacts with serotonin receptors and other systems that regulate mood and stress responses. Many users report feeling calmer and more balanced without the risk of disorientation or paranoia

• Delta-8 THC: While Delta-8 THC’s psychoactive effects can help some users unwind or feel more relaxed, they have the potential to exacerbate anxiety in others, particularly at higher doses. This unpredictability makes Delta-8 less reliable than CBD for anxiety relief.

If you want something for your anxiousness, CBD is generally the safer and more consistent option.

Delta-8 vs CBD for Pain Relief

Both Delta-8 THC and CBD demonstrate potential for managing pain, but their approaches differ:

• CBD: Works indirectly to reduce inflammation and modulate pain perception through its interaction with CB2 receptors, TRPV1, and PPARγ. This makes CBD especially useful for inflammatory conditions like arthritis or localized pain when applied topically.

• Delta-8 THC: Binds to CB1 and CB2 receptors, modulating pain signaling and potentially offering relief for neuropathic and physical pain. Its mild psychoactive effects may help users feel more relaxed and disconnected from discomfort. While it shows promise as a pain-relief option, more research is needed to confirm its specific efficacy for neuropathic pain compared to other cannabinoids or therapies.

For pain relief, the choice often depends on the type and severity of pain. CBD is preferred for everyday use or long-term inflammatory management, while Delta-8 may be an option for those seeking stronger, short-term relief—provided they are comfortable with its psychoactive effects.

Ultimately, CBD, with its well-documented safety and efficacy, is a more versatile and dependable option for a wide range of wellness needs.

Does Consumption Method Matter?

Both CBD and Delta-8 THC are lipophilic, meaning they are best absorbed when taken with or around a meal that includes fatty foods. Consuming these cannabinoids on a full stomach can boost their bioavailability, potentially increasing the depth and duration of their effects. 

This “food effect” is especially notable for CBD, with research showing significantly higher blood levels when it’s taken alongside a high-fat meal.

What Does This Mean for Potential Benefits?

• CBD: May provide anti-inflammatory, anxiolytic, and pain-modulating effects without producing a pronounced “high.”

• Delta-8 THC: Offers milder psychoactive effects than Delta-9 THC, potentially helping with relaxation, appetite stimulation, and stress relief, but still carries psychoactive risks.

Both cannabinoids affect the ECS in unique ways, and their overall impact often depends on your dose, method of consumption, and individual physiology. 

Production and Quality

How Is CBD Extracted?

Modern CBD products often rely on two main extraction approaches: CO₂ extraction and solvent-based methods (commonly using ethanol). 

CO₂ extraction is prized for its ability to preserve cannabinoids, terpenes, and other beneficial compounds without leaving behind chemical residues. 

We take this a step further by using a specialized solventless extraction method called Cellular Deconstruction™ Technology method. This approach breaks down plant cells more thoroughly, aiming to capture the full array of beneficial elements from the hemp plant.

These “whole spectrum” extracts can contain not just CBD, but also other cannabinoids, terpenes, and flavonoids that together provide comprehensive benefits of “entourage effect.”

Delta-8 Safety Concerns

Unlike CBD, which can be extracted directly from hemp, Delta-8 THC tends to occur in only trace amounts. 

This often leads to the use of chemical processes that convert CBD into Delta-8 at scale (commercial quantities). One concern is whether any residual chemicals or solvents remain in the end product, which can pose health and safety risks. 

Some manufacturers have implemented tightened quality controls to minimize these risks. Even so, you should remain alert: Certificates of Analysis, Third-party Lab Testing and transparent sourcing are essential to ensure that you’re getting a safer product.

Regardless of whether you’re buying CBD or Delta-8, third-party testing is a key indicator of product quality. 

Independent labs evaluate cannabinoid content, check for residual solvents, and screen for potential contaminants like heavy metals. Trusted brands provide these lab results upfront, helping consumers make informed decisions about their wellness products.

Conclusion

CBD offers many benefits without intoxication, making it ideal for daily stress management, inflammation support, and overall well-being.

While Delta-8 THC has gained recognition as a "milder" alternative to traditional THC, the alarming rise in poison center cases—nearly 10,000 between 2021 and 2024—raises serious safety concerns. 

If you want the benefits of THC, traditional Delta-9 THC products are a safer, more effective option. 

Cannovia’s Delta-9 THC products undergo rigorous testing and quality control, unlike many Delta-8 products currently flooding the market.