What is CBG? A Beginner’s Guide to Its Uses and Benefits.

What is CBG

If you’re a health and wellness enthusiast, you’re no stranger to THC and CBD. Maybe you’re already taking these substances and experiencing better health as a result.

Have you ever heard of CBG? Chances are, you probably haven’t.

CBG (cannabigerol)  is one of the most promising natural supplements out there. But before you buy, let us tell you what is and how it works.

Go here if you were looking to buy CBG oil instead.

What is CBG?

Cannabigerol (CBG) is a minor cannabinoid found in the Cannabis Sativa – L plants. CBG is called “The Mother Cannabinoid” because it is the precursor for other cannabinoids including CBD and CBG1. In other words, all cannabinoids start as CBG. It is non-intoxicating and non-addictive.

While pretty much any hemp or cannabis plant contains some CBG, only young cannabis plants produce appreciable amounts of it.

As the plant grows, the CBGA (Cannabigerolic Acid, an acidic form of CBG) is naturally converted into CBDA and THCA, which can later be converted into CBD and THC.

The CBG in cannabis plants can become THC (marijuana) or CBD (hemp), depending on the type of plant. This reduces the CBG levels in the plants. By the time the plants are mature enough to harvest, they have very little CBG, less than 1%2.

Cannabinoids are biologically active compounds that interact with the body’s endocannabinoid system (ECS). The endocannabinoid system is a network of receptors and neurotransmitters that regulate a variety of important functions, including mood, appetite, pain perception, inflammation, and more.

Minor cannabinoids are compounds found in the cannabis plant that occur in lower concentrations than THC (tetrahydrocannabinol) and CBD (cannabidiol). THC and CBD are the major cannabinoids. There are many minor cannabinoids in the cannabis plant, including Cannabigerol (CBG), Cannabinol (CBN), Cannabidivarin (CBDV), Cannabichromene (CBC), and Tetrahydrocannabivarin (THCV).

While THC is the best-known cannabinoid thanks to its psychoactive effects, CBD has been getting a lot of attention lately for its potential therapeutic benefits.

CBG is beginning to emerge as a potent player in the world of natural health.

Compared to CBD, CBG has a similar molecular weight and very similar molecular mass. And that means it has similar health properties, too, but more on this later.

Unlike THC and CBD, CBG is not produced by trichomes on the cannabis plants and hemp plants. Instead, it’s produced by cannabigerolic acid (CBGA), which is then converted into other cannabinoids like THCA and CBDA via decarboxylation.

Like CBD, CBG is non-intoxicating and doesn’t have psychoactive effects like THC.

CBG products are often coupled with CBD because the two cannabinoids can provide complementary benefits, such as decreasing inflammation and pain.

CBG was first isolated in 1964 by Israeli scientist Raphael Mechoulam3. However, it wasn’t until the early 2010s that researchers began to study CBG more closely. This can be due to the fact that CBG is present in such small quantities in most cannabis strains.

In order to study CBG, researchers had to develop new ways to grow cannabis strains that were high in CBG like Jack Frost CBG, White CBG and Super Glue CBG.

Today, researchers are studying CBG for a variety of health benefits. Some early evidence suggests that it may have robust anti-inflammatory, analgesic, antifungal effects, and more.

What Does CBG Do?

CBG works by interacting with the endocannabinoid system, which is responsible for maintaining homeostasis or harmony in our bodies, despite the external stressors4.

CBG may offer powerful anti-inflammatory effects without the ‘high’ that comes with THC. This means it can’t cause euphoria because CBGA, the acidic form of CBG, doesn’t bind to the same neurological targets as its cousin THC does5.

Instead CBG is thought to work behind the scenes by reducing chronic stress and inflammation in your body6.

CBG is also thought to strengthen the function of anandamide7, a neurotransmitter in the brain which regulates pleasure and motivation, appetite and sleep, and pain perception.

Anandamide is often called the bliss molecule because of its ability to enhance the feelings of happiness8. It is one of the most important endocannabinoids produced in our bodies.

The origin of this term comes from ananda, which means pleasure, enjoyment and happiness.

Moreover, CBG may affect certain chemicals in the body to protect the brain and nerves and reduce swelling.

CBG and Cannabinoid Receptors

CBG binds to CB1 and CB2 cannabinoid receptors, CB1 is found in the central nervous system and CB2 is found in the body and immune system.

CB1 receptors are primarily found in the nervous system and brain, while CB2 receptors are located in the immune system and other areas of the body.

What Are The Benefits of CBG?

CBG shows promise in the treatment of a variety of conditions and ailments. Some potential uses and potential benefits of CBG include:

A Healthier Brain

A man in a suit, thinking hard.

One small patient survey found that people reported CBG helped them reduce their anxiety and also ease stress9. CBG is a potential neuroprotectant and may also improve learning abilities as well as memory formation. A study conducted by University of Aberdeen in 2009 found that CBG blocks a brain-based 5HT1A receptor, involved in the regulation and production of serotonin levels10.

In 2015, research was conducted on mice by the Department of Biochemistry and Molecular Biology At Complutense University of Madrid, the scientists found that CBG could be extremely effective at reducing nerve cell damage and inflammation due to its antioxidant properties11. Inflammation and oxidative stress both play major roles in the development of neurodegenerative diseases.

A 2018 study recently highlighted that CBG may reduce inflammation in the brain12. It appears to do this by working through the brain’s PPAR receptors. Known as the ‘nuclear receptor,’ PPAR activation helps your genetic and epigenetic wiring get expressed in the best ways possible.

When PPAR is activated, it leads to an increase in the number of new neurons created in the hippocampus, a region of the brain involved in memory and learning. Additionally, PPAR activation has been shown to improve the function of existing neurons, making them more efficient at transmitting signals.

Furthermore, PPAR activation has been linked to increased levels of BDNF, a protein that helps to protect and repair neuronal cells.

CBG could also play a potential role in improving impaired prefrontal cortex functioning, which plays a major role in regulating focus, decision making, motivation, brain fog and more.

Better Gut Health

CBG has the potential to improve gut health because of its antibacterial, anti-inflammatory properties. CBG may also fight against the ‘bad’ bacteria that cause intestinal inflammation.

CBG has also been shown to have powerful antibacterial properties. A recent study showed that CBG was effective against methicillin-resistant Staphylococcus aureus (MRSA), a type of bacteria that is resistant to antibiotics13.

Ancient cultures of the past actually used CBG, in the form of raw cannabis leaves – to ward off parasites!

In Shushruta Samhita, written by an Indian physician and surgeon Shusruta in the 6th century BCE, cannabis was recommended for inducing appetite, phlegm, catarrh and diarrhea.

Recent research has also confirmed the use of hemp for medical purposes across ancient Egypt and China.

Improved Mood

A woman on a balcony, enjoying the sunlight. Their arms are spread wide.

Thankfully for us, gut health doesn’t exist in isolation, which means that improving it can tangibly impact other aspects of your health and/or mood14. Researchers call the gut a ‘second brain’ for a reason.

CBG’s may lead to clearer thinking, less brain fog, and improved mood because of its antimicrobial properties.

Moreover, CBG has been shown to interact with serotonin receptors, a neurotransmitter responsible for regulating mood and social behavior. Low serotonin levels have been linked to depression and anxiety, so CBG’s ability to interact with this neurotransmitter may help improve their symptoms.

Better Relaxation

CBG may help to reduce anxiety and promote peace and relaxation by boosting your brain’s GABA levels. GABA is one of your brain’s most important neurotransmitters, and adequate levels of it help both your muscles and mind relax.

“Cannabigerol (CBG) exhibits GABA uptake inhibition to a greater extent than THC or CBD,” explains the above report. This interaction may help to reduce anxiety and promote peace and relaxation.

GABA is a neurotransmitter that helps relax muscles and other structural substances. This softening also has mental benefits, so CBG’s effects on GABA may also mean good things for your mood. CBG might be just the thing to help you keep calm and carry on.

CBG May Reduce Inflammation

Recent shows that CBG may reduce inflammation in several areas of the human body15. In addition to improving gut health, CBG’s has the potential to do great things for cognitive function, athletic recovery, sleep, hygiene, longevity, and more.

According to a study published in the journal Molecules, CBG derivatives have been shown to possess anti-inflammatory and analgesic properties.

According to recent peer reviewed studies, CBG is an effective means of reducing inflammation in irritable bowel syndrome (IBS), or inflammatory bowel disease–a problem that millions suffer from today.

Improved muscle control

A woman doing yoga in the cobra pose, demonstrating flexibility and strength.

The benefits of CBG oil don’t stop at your brain. Cannabigerol can also help you recover faster after a tough workout! The interaction with GABA receptors we mentioned means it can help soothe your tense, sore, or tired, allow them some much-needed rest, while alleviating minor aches & pains16.

Which means that when the time comes for an even more intense session (or just everyday living), you’ll be more than ready to go.

Think of it as a muscle relaxant but for your brain! The interaction between CBG and the GABA receptors we mentioned above means that this substance could help you push yourself to new limits during workouts or when you’re stressed.

CBG and Irritable Bowel Syndrome (IBS)

According to latest research, CBG has shown potential in aiding digestion and dealing with symptoms of various digestive issues, including Irritable Bowel Syndrome (IBS)17.

IBS is a medical condition that causes stomach pain, decreased GI motility, and digestive distress.

A 2019 study suggests that IBS and Inflammatory Bowel Disease (IBD) may be caused by Clinical Endocannabinoid Deficiency (CED)18.

According to this study, chronic inflammation and IBS symptoms appear when the body is unable to produce endogenous cannabinoids.

CBG interacts with the body’s endocannabinoid system and may have anti-inflammatory and analgesic (pain-relieving) effects. Specifically, research indicates CBG may have therapeutic potential for IBS and IBD, as well as arthritis, autoimmune disorders, and other inflammatory conditions.

However, it’s important to note that while preliminary findings are promising, more research is still needed to support these claims.

Please note that CBG has not been medically proven to prevent, treat, or cure IBS.

Huntington’s Disease

Huntington’s disease is a genetic disorder that causes the progressive breakdown of nerve cells in the brain.

In experiments with mice, CBG was shown to decrease the death rate of striatal neurons and reduce inflammation markers19.

This resulted in improved motor deficits and reduced Huntington aggregates, the mutant protein responsible for the disease. This suggests neuroprotective properties of CBG.

To put it simply, in mice, this non-psychoactive cannabinoid protected brain cells, reduced inflammation, and improved movement. It even tackled the disease’s “culprit protein,” offering a glimmer of hope for future treatments.

Moreover, CBG had a significant beneficial effect on at least seven genes linked to Huntington’s Disease. The cannabinoid was able to partially normalize the expression of the genes, all of which were impaired in the R6/2 mice.

Please note that CBG has not been medically proven to prevent, treat, or cure Huntington’s disease.

Healthier Skin

CBG can reduce inflammation, redness, and improve skin barrier function. CBG can inhibit the growth of harmful skin bacteria20.

In a study published in 2015, scientists found that CBG could also be helpful in treating dry skin and it can also help make your skin smoother, and softer21.

What is the Difference Between CBD and CBG?

Both CBG and CBD interact with your endocannabinoid system, but they work in different ways. While CBD is known to bind to TRPV1 ionotropic cannabinoid receptors in the endocannabinoid system, CBG seems to interact directly with the brain’s CB1 and CB2 receptors.

This difference may explain why CBG has potential therapeutic benefits for conditions like inflammation, allowing you to get all of the mental and physical health benefits without the ‘high’ that comes with THC.

CBG and CBD both have anti-inflammatory and antimicrobial properties. Some people also use CBG to help relieve symptoms of gastrointestinal disorders.

Here are some key differences between CBD and CBG:

  • CBD is a major cannabinoid, meaning cannabis usually contains higher levels of CBD than CBG. CBG is a minor cannabinoid.
  • CBD is known for its relaxing effects, while CBG is better suited for those who want a cannabinoid that can boost productivity and improve focus.


CBG has more powerful antibacterial effects than CBD, which makes it especially promising as a cream or topical.

A recent study affirmed that “CBG proved to be marvelous at tackling pathogenic bacteria.”

CBG is also more stimulating than other cannabinoids. CBD, on the other hand, becomes sedating enough at high doses that many people use it as a sleep aid.

The complementary health benefits of each of these cannabinoids make it the perfect health couple to improve your day!

While more research is needed to determine the full extent of their benefits, CBD and CBG are both promising compounds with a wide range of potential applications.

What is CBG Oil?

It’s a tincture or oil whose active ingredient is CBG.

Most CBG oils are only about 1-3% CBG by weight – the rest of the oil constitutes an inactive carrier oil like MCT oil or coconut oil. But that tiny percentage actually provides more than enough CBG to activate your body’s endocannabinoid system and get you back into balance.

It is a powerful and fast-acting supplement that may be able to help with many different health conditions, from skin problems to digestive issues to mood disorders.

Whether you are looking for an alternative treatment for chronic pain or simply want a more balanced mood and sense of well-being, CBG may be able to help.

How to take CBG oil?

Person holding a dropper with CBG oil above an open bottle, demonstrating how to take it

CBG oil is used just like any other hemp/CBD oil might be. You simply place a few drops under your tongue, hold them there for a while, then ingest fully. it is best absorbed when you treat it like a true sublingual.

The dosing is similar, too. You can micro-dose throughout the day or take large doses all at once — depending on what your particular goals are. Many people like taking their CBG in the morning in order to make the most of its energizing effects.

How Does CBG Make You Feel?

CBG does not have psychoactive effects, so it won’t make you feel “high” or intoxicated. But it can help balance your body’s responses to daily stressors, helping you feel calmer when overwhelmed.

It’s a popular choice for people who are looking to boost their productivity, energy, and motivation naturally, whether at school, work, or out and about.

Some people report feeling more alert and focused after taking CBG, while others say that it helps to reduce anxiety and promote relaxation.

CBG may help with brain fog and improve focus and concentration by reducing inflammation in the brain and increasing GABA levels.

CBG may have anti-anxiety effects because of its interaction with anandamide. People report that CBG brightens up their day and relieves mental fatigue.

There is some anecdotal evidence which suggests that CBG can lead to a healthy appetite.

We cover CBG’s effects in detail in another article.

How to Include CBG Oil into Your Daily Routine

A pair of glasses next to a laptop

We created our CBD + CBG oil Drops specifically to take advantage of CBG’s energizing and awakening effects. By blending CBD’s benefits with CBG’s ability to promote physical energy and mental alertness. We have crafted a hemp-powered duo that supports your general well-being and daily momentum.

CBG and CBD work together to make them the perfect health couple to get you through your day seamlessly.

Most Cannovians use WAKE UP CBD + CBG Oil to get its amazing energizing benefits and attack their day with full force and use our GOODNIGHT CBN + CBD Oil Drops to end their long, tiring day and drift into dreamland!

What Are the Side Effects Of CBG?

Although not enough clinical trials have been done on humans yet to determine possible side effects of CBG, studies suggest that it is generally well tolerated. In fact, in the few clinical trials done with mice where high doses were used, there were no major negative or adverse effects.

Like any substance, it can have potential side effects which are very minor. Here are some of the most common side effects reported:

  • Dry Mouth
  • Dry Eyes
  • Dizziness
  • Changes in Appetite

It’s important to note that everyone’s body is different and these effects can vary from person to person.


What is CBG?

CBG is a cannabinoid, which just means it comes from the cannabis/hemp plant family. CBG’s classification as a cannabinoid also means it can interact with your body’s endocannabinoid receptors.

Does CBG get you high?

CBG has no psychotropic effects, so it will not give you a high.

What is CBG Oil?

It’s a tincture or oil with CBG as its active ingredient. Most CBG oils are only about 1-3% CBG by weight — the rest of the oil is composed of an inactive carrier oil like MCT oil or coconut oil. It is used just like any other hemp/CBD oil might be.

What does CBG do?

To put it super simply, CBG may offer powerful anti-inflammatory effects without the ‘high’ that comes with THC or other cannabinoids. CBG can’t cause euphoria because it simply can’t bind to the same neurological targets that THC does.

Will CBG show on a drug test?

No, Cannovia’s WAKE UP drops use CBG and CBD isolate, so there is 0% THC.

As always, consult your doctor or professional medical advice before relying on CBG or supplements if you’re struggling with a serious health condition.


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